Pulse Diagnosis

Pulse diagnosis has been credited with helping clinicians discover incredible details about patient physiology for the past two thousand years. Can advances in science and technology help us better understand this diagnostic art?


Chu, Yu-Wen, et al. "Using an array sensor to determine differences in pulse diagnosis—Three positions and nine indicators." European Journal of Integrative Medicine 6.5 (2014): 516-523.

Chung, Yu-Feng, et al. "How to standardize the pulse-taking method of traditional Chinese medicine pulse diagnosis." Computers in biology and medicine 43.4 (2013): 342-349.

Tang, Anson Chui Yan, Joanne Wai Yee Chung, and Thomas Kwok Shing Wong. "Validation of a novel traditional Chinese medicine pulse diagnostic model using an artificial neural network." Evidence-based complementary and alternative medicine 2012 (2012).

Wilcox, Christopher S., et al. "Nitric oxide mediates renal vasodilation during erythropoietin-induced polycythemia." Kidney international 44.2 (1993): 430-435.

Késmárky, Gábor, et al. "Plasma viscosity: a forgotten variable." Clinical hemorheology and microcirculation 39.1–4 (2008): 243-246.

Zhao, Xia, et al. "Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive rats." Hypertension Research 31.8 (2008): 1619.

Yoon, Sook Hyang, et al. "An objective method of pulse diagnosis." The American journal of Chinese medicine 15.03n04 (1987): 147-153.

Paulson, O. B., et al. "Influence of carbon monoxide and of hemodilution on cerebral blood flow and blood gases in man." Journal of applied physiology 35.1 (1973): 111-116.

 Safar, Michel E., Xavier Girerd, and Stéphane Laurent. "Structural changes of large conduit arteries in hypertension." Journal of hypertension 14.5 (1996): 545-555.

Grotta, J., et al. "Whole blood viscosity parameters and cerebral blood flow." Stroke 13.3 (1982): 296-301.

Charache, S., and V. MacDonald. "Increased blood viscosity in a patient with sickle cell anemia." Blood cells 8.1 (1982): 103-109.

Cabrales, Pedro, Amy G. Tsai, and Marcos Intaglietta. "Hemorrhagic shock resuscitation with carbon monoxide saturated blood." Resuscitation 72.2 (2007): 306-318.

Letcher, Robert L., et al. "Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects: role of fibrinogen and concentration." The American journal of medicine 70.6 (1981): 1195-1202.

Penney, David G. "Hemodynamic response to carbon monoxide." Environmental Health Perspectives 77 (1988): 121-130.

Tsai, Amy G., et al. "Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion." American Journal of Physiology-Heart and Circulatory Physiology (2005).

Forst, T., et al. "Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na+, K+-ATPase activity in diabetes mellitus type I." Clinical Science 98.3 (2000): 283-290.

Luo, Ching-Hsing, et al. "Possibility of quantifying TCM finger-reading sensations: I. Bi-sensing pulse diagnosis instrument." European Journal of Integrative Medicine 4.3 (2012): e255-e262.

Boutouyrie, Pierre, et al. "Effects of acupuncture on radial artery hemodynamics: controlled trials in sensitized and naive subjects." American Journal of Physiology-Heart and Circulatory Physiology 280.2 (2001): H628-H633.

Takayama, Shin, et al. "Radial artery hemodynamic changes related to acupuncture." Explore 6.2 (2010): 100-105.

Li, B. Y., et al. "Characteristics of sublingual vein and expressions of vascular endothelial growth factor and hypoxia-inducible factor 1alpha proteins in sublingual tissues of Beagle dogs with portal hypertension." Zhong xi yi jie he xue bao= Journal of Chinese integrative medicine 7.5 (2009): 463-467.

Wang, Wei Kung, et al. "Effect of acupuncture at Hsien-Ku (St-43) on the pulse spectrum and a discussion of the evidence for the frequency structure of Chinese medicine." The American journal of Chinese medicine 28.01 (2000): 41-55.

Ng, Maggie, Alice YM Jones, and L. C. Cheng. "The role of Acu-TENS in hemodynamic recovery after open-heart surgery." Evidence-based complementary and alternative medicine 2011 (2011).

Takayama, Shin, et al. "The herbal medicine Daikenchuto increases blood flow in the superior mesenteric artery." The Tohoku journal of experimental medicine 219.4 (2009): 319-330.

Brandt, Mathias C., et al. "Effects of renal sympathetic denervation on arterial stiffness and central hemodynamics in patients with resistant hypertension." Journal of the American College of Cardiology 60.19 (2012): 1956-1965.

Nichols, Wilmer W. "Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms." American journal of hypertension 18.S1 (2005): 3S-10S.

Tamura, H., et al. "Different changes in resistance index between uterine artery and uterine radial artery during early pregnancy." Human reproduction 23.2 (2007): 285-289.

Guo, Qing-Li, et al. "A wavelet packet based pulse waveform analysis for cholecystitis and nephrotic syndrome diagnosis." 2008 International Conference on Wavelet Analysis and Pattern Recognition. Vol. 2. IEEE, 2008.

Wang, Kuan-Quan, et al. "TCPD based pulse monitoring and analyzing." Proceedings. International Conference on Machine Learning and Cybernetics. Vol. 3. IEEE, 2002.

Zhang, Dongyu, et al. "Wavelet based analysis of doppler ultrasonic wrist-pulse signals." 2008 International Conference on BioMedical Engineering and Informatics. Vol. 2. IEEE, 2008.

Velik, Rosemarie. "An objective review of the technological developments for radial pulse diagnosis in Traditional Chinese Medicine." European Journal of Integrative Medicine 7.4 (2015): 321-331.  

Joshi, Aniruddha, et al. "Nadi tarangini: A pulse based diagnostic system." 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2007.

Zhang, Dong-Yu, et al. "Wrist blood flow signal-based computerized pulse diagnosis using spatial and spectrum features." Journal of Biomedical Science and Engineering 3.04 (2010): 361.

ZHANG, Jun-li, et al. "Detection of waveform characteristic of pulse wave and analysis of its related partial hemodynamic changes [J]." Biomedical Engineering and Clinical Medicine 2 (2008): 104-107.

Wang, Yiqin, et al. "Study on intelligent syndrome differentiation in traditional Chinese medicine based on information fusion technology." 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW). IEEE, 2010.

Chen, Yinghui, et al. "Pattern classification for Doppler ultrasonic wrist pulse signals." 2009 3rd International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2009.

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