Traditional Concepts, Modern Physiology

Water distribution: Where there is dampness, bacteria proliferate. Where there is dryness, cells become damaged.

As dryness and dampness get worse the low grade inflammation goes up.

This generalized immune response causes bacteria in the damp areas and your human cells to signal changes in DNA expression to become snotty.

This leads to systemic mucus in the intestines and the inflammation contributes to arterial plaques, amyloid plaques, and other gatherings of nasty

Qi and Blood

The blood carries gas.

Gasses in the blood open and close the vessels and cause steady cardiac contractility.

Blood carries gasses, signaling gases and gasotransmitters.

Blood carries heat shock proteins and compounds which can create chain reactions of anti-inflammatory effects throughout the body

Dyness causing damp:

Lack of thirst

Less water

failure to wash the intestines like a low river becoming stagnant

Qi (gas) /blood (si wu tang endogenous antioxidants)

damp/dry

mucus/ inflammation

Deregulation of qi becomes dryness, and finally fire.

Deregulation of gasses in the blood contribute to progressively increasing inflammation and poor fluid physiology.

Deregulated blood becomes filled with bacteria, lipids, and eventually the relationship with inflammation signals mucus secretion.

凡泄泻之病,多由水谷不分,故以利水为上策。-景岳全书,泄泻

Diarrhea is mainly cased by a failure to separate water and grain. Therefore, to disinhibit water is the best strategy.-Jing Yue Quan Shu

Sodium Potassium ATP Ase

Control the water pumps

Nitric oxide stimulates its release. Too much or too little cause its deregulation.

Aquaporins

Gut dysbiosis (excess)

Deregulation of gasotransmitters influencing Na K Atpase

Within dampness there is dryness.

Spleen Engenders Phlegm

Most mucus produced in the body is in the GI tract

Produced along Epithelium

NO shown to maintain gastric mucosal integrity

Signal mucus in nasal sinuses

Spleen Governs the Flesh and Muscles

Heat shock proteins

Atrophy brought on by INOS in immobilized limbs

Nitric oxide treatment attenuates muscle atrophy

Spleen Governs the Movement of Gastric Juice

No regulates gastric acid

Stimulates or inhibits acid depending on dose

Spleen Governs the Postheaven

Gene expression?

NO directly influence the activity of transcription factors

modulates upstream signaling cascades, mRNA stability and translation,

processing of the primary gene products

Spleen Yang is Rooted in Kidney Yang

Inflammatory joint problems from nsaids, GI problems,

HPA thyroid axis

Adrenal response, shit your pants in fear, evolutionary adaptation, vomit then run

ACTH and the microbiota

Heart and Small intestine

These results suggest that intestinal changes have relevance in the induction of systemic influence, as we will see subsequently. The small intestine wall presents both thickening and increase of the collagen tissue, which is proportional to the severity of heart failure. http://www.scielo.br/scielo.php?pid=S0066-782X2012000300011&script=sci_arttext&tlng=en

Heart and Small intestine

Cardiovascular-Decreased cardiac function can reduce bowel perfusion and so clearly impairs the function of the intestinal barrier.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4131065

http://www.scielo.br/scielo.php?pid=S0066-782X2012000300011&script=sci_arttext&tlng=en

Intestines to Heart

Systemic inflammation leading to deregulation of nitric oxide and heart disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131065/