Lab tests which reflect Dampness:
With Damp: IL-2↑ IL-8↑
Gastric mucosa SOD↓
Gastric mucosa MDA↑
Aquaporins and water metabolism:
Couli is a traditional concept relating to pores found everywhere in the body which are crucial for water transport. Aquaporins fit this description.
Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of water, and in some cases, small solutes across the membrane.
Aquaporins－2(AQP2) in urine decreases with damp.
AQP2 is expressed in the kidney collecting ducts, where it shuttles between the intracellular storage sites and the plasma membrane under the control of antidiuretic hormone (ADH). Mutations of AQP2 result in diabetes insipidus.
AQP3 is present in the kidney collecting ducts, epidermis, urinary, respiratory, and digestive tracts. AQP3 in organs other than the kidney may be involved in the supply of water to them.
AQP4 is present in the brain astrocytes, eye, ear, skeletal muscle, stomach parietal cells, and kidney collecting ducts.
AQP5 is in the secretory cells such as salivary, lacrimal, and sweat glands. AQP5 is also expressed in the ear and eye.
AQP6 is localized intracellular vesicles in the kidney collecting duct cells.
AQP7 is expressed in the adipocytes, testis, and kidney.
AQP8 is expressed in the kidney, testis, and liver. AQP9 is present in the liver and leukocytes. AQP10 is expressed in the intestine. The diverse and characteristic distribution of aquaporins in the body suggests their important and specific roles in each organ.
San Ren Tang found in “Wind” and “Peak” tea regulates AQP2 and HPA axis
Huang qi, found in “Lift” pills also regulates aquaporins
Substance P (SP) and So-matostatin (SS) decreases in damp mice.
San Ren Tang regulates SP and SS.
Conditional pathogenic bacteria such as Escherichia coli, Enterococcus, and Clostridium are overgrown.
Bacillus will be found on around 72% of tongue biofilms.
CRH, ACTH and Cor increase in damp. San Ren Tang affects HPA axis by regulating CRH, ACTH and Cor
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