Heaven and Earth: Gas and Microbiota

Heaven= Gases

Earth= Bacteria

Early chemists were also alchemists

The big picture helps refine where to look for the small picture

Heaven-3

Creates Earth 4

Qi solidifies into substance

Gasses condense into gravity, condensation transfers etherial to material

Gasotransmitters- Gaseous signaling molecules important for the body’s homeostasis.

Microbiota- “The ecological community of commensal, symbiotic and pathogenic microorganisms that literally share our body space.

Life breathes

Who are you?

}Where you store fat

}Food cravings

}Introversion & extroversion

}Extreme sports, cat or dog person.

}ADHD

}Autism

}Obesity

}Schizophrenia/bipolar disorder

}Anxiety

}Fibromyalgia

}Asthma &Allergies

Who raised you?

Good (Fairy) bacteria like Bifidobacterium could play a role in brain development

Gut bacteria play a role in social behavior

Self cultivation

Your grandmother’s life is in your gut decisions

Aging guts lack diversity

Gas in the body

Gas

Signaling gas

Gasotransmitters

●Since 1990’s scientists have discovered that certain gases act as signaling molecules.

●Help regulate homeostasis in the body.

●Regulate the endocrine system and inflammation

Gasotransmitters on Communication Networks

Ion pumps

Microtubules

Quantum tunneling

Nerves

Blood circulation

Biophotons

Electromagnetic radiation field

Gasotransmitters on Hormones

Systemic functions such as the HPA axis

https://www.ncbi.nlm.nih.gov/pubmed/25287536

Gasotransmitters on cellular function and communication

Cellular function and communication

Proliferation,

Inflammation

Cellular metabolism

Oxygen sensing

Gene transcription.

Apoptosis- Programmed cell death to clear away decaying tissue

Clean out potentially cancerous cells with DNA damage

Maintain homeostasis

https://www.ncbi.nlm.nih.gov/pubmed/8101558

Gasotransmitters mediate Immune Function and Inflammation

https://www.ncbi.nlm.nih.gov/pubmed/11577346

https://www.ncbi.nlm.nih.gov/pubmed/28398086

Hydrogen Sulfide (kidney qi)

Controls peripheral nerve degeneration and regeneration

Ameliorates Kidney Lesions in Type 2 Diabetes

Response recovery from early life trauma

Excess or deficiency

They can be empty or full. .

To function they require “Sufficient Physiological concentrations.”

“Intracellular distribution”

https://www.physiology.org/doi/abs/10.1152/ajpregu.00045.2011

Aging relates to Lowered intracellular communication

Nitric oxide donors

At high doses act on gastric parietal cells, resulting in inhibition of the stimulated acid secretion

At lower doses, facilitate histamine release from histamine-containing cells, leading to the increased acid secretion

H2S synthesis from the microbiome contributes substantially to 'tissue levels' of H2S

In circumstances of anoxia or hypoxia, H2S can 'rescue' mitochondria.

Prevents oxidize damage and stand in for oxygen

Of the 395 bacterial phylotypes, 244 (62%) were novel, and 80% represented sequences from species that have not been cultivated.

Most of the inferred organisms were members of the Firmicutes and Bacteroidetes The Firmicutes phylum.

Most (95%) of the Firmicutes sequences were members of the Clostridia class.

Nitric Oxide producer:Increased luminal production by lactobacilli and bfidobacteriae

Increase consumption by E. coli and S. aureus

Nitric Oxide eaters

Leaky gut

Inflammation and gut dysbiosis contributes to leaky gut

“Improper diet leads to stomach disease. When ill, the spleen becomes affected leading to taxation. When taxed, the spleen fails to move liquid and stomach diseases result” Li Dong Yuan

The prolonged production of bacterial NO with sulphide can explain the initiation and barrier breakdown central to the pathogenesis of ulcerative colitis.

Intestinal microbiota has been shown to influence intestinal barrier function and the brain-gut axis

Microbiota Influence

Colon cancer

Inflammatory bowel disease

Irritable bowel syndrome

Obesity/Diabetes

Cardiovascular disease

Fibromyalgia

hypothalamic pituitary adrenal axis which has regulatory influences on:

Digestion

Immune function

Emotions

Energy storage and expenditure

Nutrient absorption and energy regulation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601187/

DNA Methylation

www.ncbi.nlm.nih.gov/pmc/articles/PMC5495071

Psycobiotics

gamma-aminobutyric acid (GABA)

serotonin (and them 5Ht)

catecholamines

acetylcholine

microbially- derived

Gut Brain Axis

bidirectional communication

nervous system

endocrine system

immune system

metabolic system

Homeostasis

System-wide and organ-specific metabolism may have components driven by gut microbial activities which suggests that the dynamics of the gut microbiome could help maintain or restore host metabolic homeostasis in disease and early onsets of metabolic deregulations.

Martin FP, Sprenger N, Yap IK, Wang Y, Bibiloni R, Rochat F, et al. Panorganismal gut
microbiome-host metabolic crosstalk. J Proteome Res. 2009;8(4):2090–105.

Martin FP, Sprenger N, Montoliu I, Rezzi S, Kochhar S, Nicholson JK. Dietary modulation of gut functional ecology studied by fecal metabonomics. J Proteome Res. 2010;9(10):
5284–95.