Heaven and Earth: Gas and Microbiota
Early chemists were also alchemists
The big picture helps refine where to look for the small picture
Creates Earth 4
Qi solidifies into substance
Gasses condense into gravity, condensation transfers etherial to material
Gasotransmitters- Gaseous signaling molecules important for the body’s homeostasis.
Microbiota- “The ecological community of commensal, symbiotic and pathogenic microorganisms that literally share our body space.
Who are you?
}Where you store fat
}Introversion & extroversion
}Extreme sports, cat or dog person.
Who raised you?
Good (Fairy) bacteria like Bifidobacterium could play a role in brain development
Gut bacteria play a role in social behavior
Your grandmother’s life is in your gut decisions
Aging guts lack diversity
Gas in the body
●Since 1990’s scientists have discovered that certain gases act as signaling molecules.
●Help regulate homeostasis in the body.
●Regulate the endocrine system and inflammation
Gasotransmitters on Communication Networks
Electromagnetic radiation field
Gasotransmitters on Hormones
Systemic functions such as the HPA axis
Gasotransmitters on cellular function and communication
Cellular function and communication
Apoptosis- Programmed cell death to clear away decaying tissue
Clean out potentially cancerous cells with DNA damage
Gasotransmitters mediate Immune Function and Inflammation
Hydrogen Sulfide (kidney qi)
Controls peripheral nerve degeneration and regeneration
Ameliorates Kidney Lesions in Type 2 Diabetes
Response recovery from early life trauma
Excess or deficiency
They can be empty or full. .
To function they require “Sufficient Physiological concentrations.”
Aging relates to Lowered intracellular communication
Nitric oxide donors
At high doses act on gastric parietal cells, resulting in inhibition of the stimulated acid secretion
At lower doses, facilitate histamine release from histamine-containing cells, leading to the increased acid secretion
H2S synthesis from the microbiome contributes substantially to 'tissue levels' of H2S
In circumstances of anoxia or hypoxia, H2S can 'rescue' mitochondria.
Prevents oxidize damage and stand in for oxygen
Of the 395 bacterial phylotypes, 244 (62%) were novel, and 80% represented sequences from species that have not been cultivated.
Most of the inferred organisms were members of the Firmicutes and Bacteroidetes The Firmicutes phylum.
Most (95%) of the Firmicutes sequences were members of the Clostridia class.
Nitric Oxide producer:Increased luminal production by lactobacilli and bfidobacteriae
Increase consumption by E. coli and S. aureus
Nitric Oxide eaters
Inflammation and gut dysbiosis contributes to leaky gut
“Improper diet leads to stomach disease. When ill, the spleen becomes affected leading to taxation. When taxed, the spleen fails to move liquid and stomach diseases result” Li Dong Yuan
The prolonged production of bacterial NO with sulphide can explain the initiation and barrier breakdown central to the pathogenesis of ulcerative colitis.
Intestinal microbiota has been shown to influence intestinal barrier function and the brain-gut axis
Inflammatory bowel disease
Irritable bowel syndrome
hypothalamic pituitary adrenal axis which has regulatory influences on:
Energy storage and expenditure
Nutrient absorption and energy regulation
gamma-aminobutyric acid (GABA)
serotonin (and them 5Ht)
Gut Brain Axis
System-wide and organ-specific metabolism may have components driven by gut microbial activities which suggests that the dynamics of the gut microbiome could help maintain or restore host metabolic homeostasis in disease and early onsets of metabolic deregulations.
Martin FP, Sprenger N, Yap IK, Wang Y, Bibiloni R, Rochat F, et al. Panorganismal gut
microbiome-host metabolic crosstalk. J Proteome Res. 2009;8(4):2090–105.
Martin FP, Sprenger N, Montoliu I, Rezzi S, Kochhar S, Nicholson JK. Dietary modulation of gut functional ecology studied by fecal metabonomics. J Proteome Res. 2010;9(10):